Contacts added to an exclusion list are permanently suppressed system wide from all of your lists
Exclusion lists are found in a tab under under contacts -> suppression in the site navigation
Exclusion lists can not be created or deleted, they exist before time
Use the Actions button on an exclusion list to permanently ban contacts from your account
Block hostile domains
Ban all contacts from an entire domain by using the Domains exclusion Action button
Use domain exclusion to block competitors, spies, bots, malware, malicious signups, common typo domains, etc